1 to 5 of 5 Results
Oct 30, 2020 - Orkin Lab
Xu, Jian; Zhen, Shao; Glass, Kimberly; Bauer, Daniel E.; Pinello, Luca; Van Handel, Ben; Hou, Serena; Stamatoyannopoulos, John A.; Mikkola, Hanna K.A.; Yuan, Guo-Cheng; Orkin, Stuart H., 2020, "Comparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis [Histone Modification]", https://doi.org/10.7910/DVN/Z6OX6R, Harvard Dataverse, V1
Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of development are unknown. Here we profile chromatin state maps, transcription factor occupancy, and gene expression profiles duri... |
Oct 30, 2020 - Orkin Lab
Xu, Jian; Zhen, Shao; Glass, Kimberly; Bauer, Daniel E.; Pinello, Luca; Van Handel, Ben; Hou, Serena; Stamatoyannopoulos, John A.; Mikkola, Hanna K.A.; Yuan, Guo-Cheng; Orkin, Stuart H., 2020, "Comparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis [Transcription Factor Binding]", https://doi.org/10.7910/DVN/P75S6Z, Harvard Dataverse, V1
Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of development are unknown. Here we profile chromatin state maps, transcription factor occupancy, and gene expression profiles duri... |
Oct 30, 2020 - Orkin Lab
Yao, Huilan; Goldman, Devorah C.; Nechiporuk, Tamilla; Kawane, Sunita; McWeeney, Shannon K.; Tyner, Jeffrey W.; Fan, Guang; Kerenyi, Marc A.; Orkin, Stuart H.; Fleming, William H.; Mandel, Gail, 2020, "Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis", https://doi.org/10.7910/DVN/RGPBWN, Harvard Dataverse, V1
Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during embryonic development. Rcor1 mutant proerythroblasts, unlike normal cells, can form... |
Oct 30, 2020 - Orkin Lab
Kerenyi, Marc A.; Zhen, Shao; Hsu, Yu-Jung; Guoji, Guo; Sidinh, Luc; O’Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H., 2020, "Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation", https://doi.org/10.7910/DVN/AVCOF5, Harvard Dataverse, V1
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide anal... |
Oct 30, 2020 - Orkin Lab
Pinello, Luca; Xu, Jian; Orkin, Stuart H.; Yuan, Guo-Cheng, 2020, "ChIP-seq analysis of chromatin state plasticity in primary human adult erythroid progenitor cells", https://doi.org/10.7910/DVN/FFPCJX, Harvard Dataverse, V1
We report a computational approach for investigation of chromatin state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distribution of H3K27me3 in 19 human cell lines. We found that high plasticity regions (HPRs) can be di... |