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Oct 30, 2020 - Orkin Lab
Yao, Huilan; Goldman, Devorah C.; Nechiporuk, Tamilla; Kawane, Sunita; McWeeney, Shannon K.; Tyner, Jeffrey W.; Fan, Guang; Kerenyi, Marc A.; Orkin, Stuart H.; Fleming, William H.; Mandel, Gail, 2020, "Identification of genes regulated by Rcor1 in CD71+, TER119- erythroid progenitors using mRNA-seq analysis", https://doi.org/10.7910/DVN/RGPBWN, Harvard Dataverse, V1
Transcription cofactor Rcor1 has been linked biochemically both to neurogenesis and hematopoiesis. Here we studied the function of Rcor1 in vivo and showed it is essential to erythropoeisis during embryonic development. Rcor1 mutant proerythroblasts, unlike normal cells, can form... |
Oct 30, 2020 - Orkin Lab
Kerenyi, Marc A.; Zhen, Shao; Hsu, Yu-Jung; Guoji, Guo; Sidinh, Luc; O’Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H., 2020, "Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation", https://doi.org/10.7910/DVN/AVCOF5, Harvard Dataverse, V1
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide anal... |