1 to 4 of 4 Results
Oct 30, 2020 - Orkin Lab
Xu, Jian; Zhen, Shao; Glass, Kimberly; Bauer, Daniel E.; Pinello, Luca; Van Handel, Ben; Hou, Serena; Stamatoyannopoulos, John A.; Mikkola, Hanna K.A.; Yuan, Guo-Cheng; Orkin, Stuart H., 2020, "Comparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis [Histone Modification]", https://doi.org/10.7910/DVN/Z6OX6R, Harvard Dataverse, V1
Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of development are unknown. Here we profile chromatin state maps, transcription factor occupancy, and gene expression profiles duri... |
Oct 30, 2020 - Orkin Lab
Xu, Jian; Zhen, Shao; Glass, Kimberly; Bauer, Daniel E.; Pinello, Luca; Van Handel, Ben; Hou, Serena; Stamatoyannopoulos, John A.; Mikkola, Hanna K.A.; Yuan, Guo-Cheng; Orkin, Stuart H., 2020, "Comparative profiling of chromatin state maps and transcription factor occupancy during human fetal and adult erythropoiesis [Transcription Factor Binding]", https://doi.org/10.7910/DVN/P75S6Z, Harvard Dataverse, V1
Gene-distal enhancers are critical for tissue-specific gene expression, but their genomic determinants within a specific lineage at different stages of development are unknown. Here we profile chromatin state maps, transcription factor occupancy, and gene expression profiles duri... |
Oct 30, 2020 - Orkin Lab
Kerenyi, Marc A.; Zhen, Shao; Hsu, Yu-Jung; Guoji, Guo; Sidinh, Luc; O’Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H., 2020, "Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation", https://doi.org/10.7910/DVN/AVCOF5, Harvard Dataverse, V1
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide anal... |
Oct 30, 2020 - Orkin Lab
Pinello, Luca; Xu, Jian; Orkin, Stuart H.; Yuan, Guo-Cheng, 2020, "ChIP-seq analysis of chromatin state plasticity in primary human adult erythroid progenitor cells", https://doi.org/10.7910/DVN/FFPCJX, Harvard Dataverse, V1
We report a computational approach for investigation of chromatin state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distribution of H3K27me3 in 19 human cell lines. We found that high plasticity regions (HPRs) can be di... |