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Oct 30, 2020 - Orkin Lab
Kerenyi, Marc A.; Zhen, Shao; Hsu, Yu-Jung; Guoji, Guo; Sidinh, Luc; O’Brien, Kassandra; Fujiwara, Yuko; Peng, Cong; Nguyen, Minh; Orkin, Stuart H., 2020, "Histone Demethylase Lsd1 is Required to Repress Hematopoietic Stem and Progenitor Cell Signatures During Blood Cell Maturation", https://doi.org/10.7910/DVN/AVCOF5, Harvard Dataverse, V1
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy of Lsd1, genome-wide anal... |
Oct 30, 2020 - Orkin Lab
Pinello, Luca; Xu, Jian; Orkin, Stuart H.; Yuan, Guo-Cheng, 2020, "ChIP-seq analysis of chromatin state plasticity in primary human adult erythroid progenitor cells", https://doi.org/10.7910/DVN/FFPCJX, Harvard Dataverse, V1
We report a computational approach for investigation of chromatin state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distribution of H3K27me3 in 19 human cell lines. We found that high plasticity regions (HPRs) can be di... |
Oct 30, 2020 - Zon Lab
Paik, Elizabeth J.; Mahony, Shaun; White, Richard M.; Price, Emily N.; DiBiase, Anthony; Dorjsuren, Bilguujin; Mosimann, Christian; Davidson, Alan J.; Gifford, David; Zon, Leonard I., 2020, "A Cdx4-Sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis", https://doi.org/10.7910/DVN/0XYJJW, Harvard Dataverse, V1
Deletion of caudal/cdx genes alters hox gene expression and causes defects in posterior tissues and hematopoiesis. Yet, the defects in hox gene expression only partially explain these phenotypes. To gain deeper insight into Cdx4 function, we performed ChIP-seq combined with gene... |